期刊
ORGANIC LETTERS
卷 19, 期 19, 页码 5212-5215出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b02482
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资金
- National Natural Science Foundation of China [U1604283, 21402041]
- Plan for Scientific Innovation Talent of Henan Province [164200510008]
- Program for Innovative Research Team in Science and Technology in University of Henan Province [15IRTSTHN003]
A direct route to branched N-allylpyrimidine analogues is herein reported via the highly regio- and enantioselective asymmetric allylation of pyrimidines with racemic allylic carbonates. With [Rh(COD)Cl](2)/chiral diphosphine as the catalyst, a range of chiral pyrimidine acyclic nucleosides could be obtained under neutral conditions in good yields (up to 95% yield) with high levels of regio- and enantioselectivities (15:1 to >40:1 B/L and up to 99% ee). Furthermore, chiral pyrimidine acyclic nucleoside bearing two adjacent chiral centers has been successfully synthesized by asymmetric dihydroxylation.
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