期刊
INDIAN JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
卷 22, 期 2, 页码 74-81出版社
WOLTERS KLUWER MEDKNOW PUBLICATIONS
DOI: 10.4103/ijoem.IJOEM_45_18
关键词
DNA repair; genetic DNA damage; health effects; pesticide exposure; reactive oxygen species
资金
- Department of Science and Technology - Science and Engineering Research Board (DST-SERB), New Delhi, India [YSS/2015/000870]
Pesticides are a mixture of chemical substances used to kill pests. Apart from their toxicity to pests, thy affect nontarget organisms. They also generate free radicals producing reactive oxygen species (ROS) which can disturb cellular pathways by inhibiting various enzymes or receptors. Pesticides also induce oxidative DNA damage, DNA adducts, and single or double strand DNA breaks. Various mechanisms of DNA repair deal with such damages and help to maintain cell integrity. Alteration in DNA repair genes modulates the individual's susceptibility towards DNA repair and various diseases. Biological monitoring provides a useful tool for the estimation of genetic risk in populations exposed to pesticides. Large numbers of evidences show that occupational exposure to pesticides in agricultural workers has been associated with an increased incidence of various diseases such as cancer, Parkinson's disease, Alzheimer's disease, reproductive disorders, and birth defects. In this review, we have discussed occupational pesticide exposure, various mechanisms of DNA damage caused by pesticides, DNA repair mechanisms, biomonitoring tools, and various diseases caused by pesticide exposure.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据