4.8 Article

Copper-Catalyzed Stereodefined Construction of Acrylic Acid Derivatives from Terminal Alkynes via CO2 Insertion

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ORGANIC LETTERS
卷 19, 期 4, 页码 854-857

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AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b03860

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  1. Ministry of Education, Culture, Sports and Technology (MEXT), Japan [26288052]
  2. Grants-in-Aid for Scientific Research [26288052] Funding Source: KAKEN

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IPrCuCl catalyzes the CO, insertion reaction undergone by a intermediate derived from alkynyltrialkylborate by a 1,2-alkyl group migration to afford alpha-alkyl acrylic acids with excellent regio- and stereoselectivities.

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