期刊
IFAC PAPERSONLINE
卷 51, 期 18, 页码 126-131出版社
ELSEVIER
DOI: 10.1016/j.ifacol.2018.09.287
关键词
Process monitoring; Low-N problem; Biopharmaceutical manufacturing
Commercial biopharmaceutical manufacturing comprises of multiple distinct processing steps that require effective and efficient monitoring of many variables simultaneously in real-time. This article addresses the problem of real-time statistical batch process monitoring (BPM) for biopharmaceutical processes with limited production history; herein, referred to as the 'Low-N' problem. In this article, we propose an approach to transition from a Low-N scenario to a Large-N scenario by generating an arbitrarily large number of in silico batch data sets. The proposed method is a combination of hardware exploitation and algorithm development. To this effect, we propose a Bayesian non-parametric approach to model a batch process, and then use probabilistic programming to generate an arbitrarily large number of dynamic in silico campaign data sets. The efficacy of the proposed solution is elucidated on an industrial process. (C) 2018, IFAC (International Federation of Automatic Control) Hosting by Elsevier Ltd. All rights reserved.
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