期刊
ORGANIC LETTERS
卷 19, 期 8, 页码 2010-2013出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b00566
关键词
-
资金
- program for the National Science Foundation of China [21372073, 21572054, 21572055]
- Fundamental Research Funds for the Central Universities
- China 111 Project
A metal-free catalytic strategy for the facile synthesis of biologically relevant molecular architectures indolizines and imidazopyridines has been developed. The process is promoted by amine and N-heterocyclic carbene (NHC) relay catalysis via Michael addition-[3 + 2] fusion of simple azaarenes and alpha,beta-unsaturated aldehydes. The preparative power is demonstrated in the synthesis of anxiolytic drug saripidem via two simple one-pot operations with overall 45% yield.
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