期刊
ORGANIC LETTERS
卷 19, 期 3, 页码 456-459出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b03591
关键词
-
资金
- National Natural Science Foundation of China [21272084, 21402058]
- self-determined research funds of CCNU from the colleges' basic research and operation of MOE [CCNU16A02001, CCNU15A05017]
A fully synthetic self-adjuvanting cancer vaccine candidate was constructed through covalent conjugation of invariant natural killer T (iNKT) cell ligand alpha-galactosylceramide (alpha GalCer) with sialyl Tn (STn), a representative tumor-associated carbohydrate antigen (TACA). This two component vaccine STn-alpha GalCer is devoid of antigenic peptide, featuring the well-defined structure with high simplicity. STn-alpha GalCer showed remarkable efficacy in inducing antibody class switching from IgM to STn-specific IgG. Subtypes of IgG antibody were primarily IgG1 and IgG3.
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