期刊
ORGANIC LETTERS
卷 19, 期 22, 页码 6228-6231出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b03171
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资金
- National Natural Science Foundation of China [21502177]
- Department of Education of Henan Province [15A150005]
- Doctoral Research Foundation of Zhengzhou University of Light Industry [2014BSJJ032]
- Youth Backbone Teachers Training Object of Zhengzhou University of Light Industry
A transition-metal-free oxidative formal [3 + 2 + 1] cycloaddition for the synthesis of symmetrical and unsymmetrical 2,4-disubstituted 1,3,5-triazines has been first demonstrated. The reaction is involved in a domino C-H amination of alkyl ethers with amidines, C-O cleavage, nucleophilic addition, condensation, and an oxidative aromatization process. Notably, two C-N bonds were constructed in one pot, and alkyl ethers were employed as a novel carbon source of 1,3,5-triazines. The preliminary mechanistic studies revealed the reaction underwent a radical pathway.
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