期刊
ORGANIC LETTERS
卷 19, 期 12, 页码 3231-3234出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b01343
关键词
-
资金
- National Natural Science Foundation of China [21325207, 21532003, 21421062]
- 111 project of the Ministry of Education of China [B06005]
A highly efficient iridium-catalyzed asymmetric hydrogenation of tetrasubstituted cyclic enones has been developed for the enantioselective synthesis of chiral cycloalkanols with three contiguous stereocenters. The C-O and C-C bonds of the enone substrates were hydrogenated sequentially in one pot with excellent enantioselectivity (92 to >99% ee) and diastereoselectivity (dr 95:5 to >99:1). The reaction provided a practical approach to all of the stereoisomers of the antiulcer drug rosaprostol.
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