4.8 Article

Formyloxyacetoxyphenylmethane as an N-Formylating Reagent for Amines, Amino Acids, and Peptides

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ORGANIC LETTERS
卷 19, 期 18, 页码 4908-4911

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AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b02382

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  1. University of Bath, EPSRC
  2. Centre for Doctoral Training in Sustainable Chemical Technologies [EP/L016354/1]
  3. Engineering and Physical Sciences Research Council [1222485] Funding Source: researchfish

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Formyloxyacetoxyphenylmethane is a stable, water-tolerant, N-formylating reagent for primary and secondary amines that can be used under solvent-free conditions at room temperature to prepare a range of N-formamides, N-formylanilines, N-formyl-alpha-amino acids, N-formylpeptides, and an isocyanide.

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