期刊
ORGANIC LETTERS
卷 19, 期 23, 页码 6372-6375出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b03229
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资金
- National Natural Science Foundation of China [21472068]
- MOE & SAFEA for the 111 Project [B13025]
One-step concurrent fluoro-trifluoromethylation across the triple bond of arylacetylenes in a syn mode is enabled by the collaboration of (phen)Cu-III(CF3)(3) and CsF that produces chemo-, regio-, and stereoselectively (Z)-alpha-fluoro-beta-CF3 styrenes. This method can be extended to achieve syn-oxy-trifluoromethylation and syn-aryl-trifluoromethylation of alkynes using phenoxides, alkoxides, or phenylboronic acid in place of CsF. It opens up new opportunities for preparing various functionalized trifluoromethylated Z-alkenes and demonstrates the potential of Cu(III)-CF3 complexes in organic synthesis.
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