期刊
ORGANIC LETTERS
卷 19, 期 8, 页码 1978-1981出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b00309
关键词
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资金
- Ministere de l'Enseignement Superieur et de la Recherche Scientifique
- Universite du Havre-Normandie
An efficient cascade transformation toward indolizine-based molecules has been developed. This process leads to the rapid construction of two C-N bonds and one C-C bond without the need of any metal catalysis. The approach involves easily accessible chromone-based Michael acceptors and propargylamine derivatives as starting materials. This cascade constitutes a novel and very competitive alternative to the well reported strategies using pyridine or pyrrole derivatives for accessing the indolizine ring with substituents at uncommon C-positions
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