期刊
ORGANIC LETTERS
卷 19, 期 23, 页码 6348-6351出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b03189
关键词
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资金
- National Natural Science Foundation of China [81503218, 81773901]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT15R63]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
Nigegladines A-C (1-3), three thymoquinone dimers, were isolated from the seeds of Nigella glandulifera. Racemic 1 possesses a unique tricyclo[5.4.0.1(2,6)]dodecane carbon skeleton, and compounds 2 and 3 are two unusual diterpenoid alkaloids with indole cores. Their structures were determined by extensive spectroscopic analyses, and that of 1 was confirmed by single-crystal X-ray diffraction. Both (+)-1 and (-)-1 exhibited significant protective effects against hypoxia/reoxygenation-induced H9c2 myocardial cell injury.
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