期刊
ORGANIC LETTERS
卷 19, 期 10, 页码 2762-2765出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b01124
关键词
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资金
- EPSRC [EP/I038071/1]
- Bristol University
- Development and Promotion of Science and Technology (DPST) Thailand
- EPSRC [EP/I038071/1, EP/K03927X/1] Funding Source: UKRI
- Engineering and Physical Sciences Research Council [EP/I038071/1, EP/K03927X/1] Funding Source: researchfish
The Zweifel reaction is a powerful method for the synthesis of alkenes, serving as a transition-metal-free alternative to the Suzuki-Miyaura reaction. To date, the scope of the Zweifel coupling has been rather narrow and has focused mainly on the coupling of vinyllithium reagents to synthesize simple aryl- and alkyl-substituted olefins. Herein, the development of a general transition-metal-free coupling process enabling the coupling of Grignard reagents or organolithiums is described. This method enables the enantiospecific synthesis of a wide variety of functionalized acyclic and cyclic olefin products.
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