相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。β-Amyrin Biosynthesis: Effect of Steric Bulk at the 6-, 10-and 15-Positions in the 2,3-Oxidosqualene Backbone on Polycyclisation Cascades
Yuri Terasawa et al.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2017)
β-Amyrin synthase from Euphorbia tirucalli L. functional analyses of the highly conserved aromatic residues Phe413, Tyr259 and Trp257 disclose the importance of the appropriate steric bulk, and cation-π and CH-π interactions for the efficient catalytic action of the polyolefin cyclization cascade
Ryousuke Ito et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2017)
Identification of Serratane Synthase Gene from the Fern Lycopodium clavatum
Yusuke Saga et al.
ORGANIC LETTERS (2017)
Heterologous biosynthesis of triterpenoid dammarenediol-II in engineered Escherichia coli
Dashuai Li et al.
BIOTECHNOLOGY LETTERS (2016)
Onocerin Biosynthesis Requires Two Highly Dedicated Triterpene Cyclases in a Fern Lycopodium clavatum
Takeshi Araki et al.
CHEMBIOCHEM (2016)
β-Amyrin Biosynthesis: Promiscuity for Steric Bulk at Position 23 in the Oxidosqualene Substrate and the Significance of Hydrophobic Interaction between the Methyl Group at Position 30 and the Binding Site
Ikki Kaneko et al.
JOURNAL OF ORGANIC CHEMISTRY (2016)
A conserved amino acid residue critical for product and substrate specificity in plant triterpene synthases
Melissa Salmon et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Friedelin Synthase from Maytenus ilicifolia: Leucine 482 Plays an Essential Role in the Production of the Most Rearranged Pentacyclic Triterpene
Tatiana M. Souza-Moreira et al.
SCIENTIFIC REPORTS (2016)
β -Amyrin Biosynthesis: The Methyl-30 Group of (3S)-2,3-Oxidosqualene Is More Critical to Its Correct Folding To Generate the Pentacyclic Scaffold than the Methyl-24 Group
Tsutomu Hoshino et al.
CHEMISTRY-A EUROPEAN JOURNAL (2015)
Are Isoursenol and γ-Amyrin Rare Triterpenes in Nature or Simply Overlooked by Usual Analytical Methods?
Hui Shan et al.
ORGANIC LETTERS (2015)
Overexpression of functional human oxidosqualene cyclase in Escherichia coli
Charlotte Kuerten et al.
PROTEIN EXPRESSION AND PURIFICATION (2015)
Squalene hopene cyclases are protonases for stereoselective Bronsted acid catalysis
Stephan C. Hammer et al.
NATURE CHEMICAL BIOLOGY (2015)
Changes in Renal Function and Oxidative Status Associated with the Hypotensive Effects of Oleanolic Acid and Related Synthetic Derivatives in Experimental Animals
Hlengiwe Pretty Madlala et al.
PLOS ONE (2015)
β-Amyrin synthase from Euphorbia tirucalli. Steric bulk, not the π-electrons of Phe, at position 474 has a key role in affording the correct folding of the substrate to complete the normal polycyclization cascade
Ryousuke Ito et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2014)
β-Amyrin Biosynthesis: The Critical Role of Steric Volume at C-19 of 2,3-Oxidosqualene for Its Correct Folding To Generate the Pentacyclic Scaffold
Tsutomu Hoshino et al.
ORGANIC LETTERS (2014)
Synthesis of Heterocyclic Terpenoids by Promiscuous SqualeneHopene Cyclases
Miriam Seitz et al.
CHEMBIOCHEM (2013)
Effect of Cation-π Interactions and Steric Bulk on the Catalytic Action of Oxidosqualene Cyclase: A Case Study of Phe728 of β-Amyrin Synthase from Euphorbia tirucalli L
Ryousuke Ito et al.
CHEMISTRY-A EUROPEAN JOURNAL (2013)
Purification, kinetics, inhibitors and CD for recombinant β-amyrin synthase from Euphorbia tirucalli L and functional analysis of the DCTA motif, which is highly conserved among oxidosqualene cyclases
Ryousuke Ito et al.
FEBS JOURNAL (2013)
Cyclization of Squalene from Both Termini: Identification of an Onoceroid Synthase and Enzymatic Synthesis of Ambrein
Daijiro Ueda et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2013)
Protein engineering of oxidosqualene-lanosterol cyclase into triterpene monocyclase
Cheng-Hsiang Chang et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2013)
The cysteine 703 to isoleucine or histidine mutation of the oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae generates an iridal-type triterpenoid
Cheng-Hsiang Chang et al.
BIOCHIMIE (2012)
Lanosterol Biosynthesis: The Critical Role of the Methyl-29 Group of 2,3-Oxidosqualene for the Correct Folding of this Substrate and for the Construction of the Five-Membered D Ring
Tsutomu Hoshino et al.
CHEMISTRY-A EUROPEAN JOURNAL (2012)
Chemo-enzymatic syntheses of drimane-type sesquiterpenes and the fundamental core of hongoquercin meroterpenoid by recombinant squalene-hopene cyclase
Yukie Yonemura et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2012)
Protein Engineering of Saccharomyces cerevisiae Oxidosqualene-Lanosterol Cyclase into Parkeol Synthase
Yuan-Ting Liu et al.
ORGANIC LETTERS (2012)
Biosynthesis of Cholesterol and Other Sterols
W. David Nes
CHEMICAL REVIEWS (2011)
Mutation of isoleucine 705 of the oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae affects lanosterol's C/D-ring cyclization and 17 alpha/beta-exocyclic side chain stereochemistry
Tung-Kung Wu et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2011)
Triterpene Functional Genomics in Licorice for Identification of CYP72A154 Involved in the Biosynthesis of Glycyrrhizin
Hikaru Seki et al.
PLANT CELL (2011)
Alteration of the Substrate's Prefolded Conformation and Cyclization Stereochemistry of Oxidosqualene-Lanosterol Cyclase of Saccharomyces cerevisiae by Substitution at Phenylalanine 699
Tung-Kung Wu et al.
ORGANIC LETTERS (2010)
Reviewing the Polyolefin Cyclization Reaction of the C-35 Polyprene Catalyzed by Squalene-Hopene Cyclase
Tsutomu Hoshino et al.
CHEMISTRY-A EUROPEAN JOURNAL (2009)
Differential Stereocontrolled Formation of Tricyclic Triterpenes by Mutation of Tyrosine 99 of the Oxidosqualene-Lanosterol Cyclase from Saccharomyces cerevisiae
Tung-Kung Wu et al.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY (2009)
Cyclization cascade of the C-33-bisnorheptaprenoid catalyzed by recombinant squalene cyclase
Jun Cheng et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2009)
Saccharomyces cerevisiae Oxidosqualene-Lanosterol Cyclase: A Chemistry-Biology Interdisciplinary Study of the Protein's Structure-Function-Reaction Mechanism Relationships
Tung-Kung Wu et al.
CHEMICAL RECORD (2008)
Protein plasticity:: A single amino acid substitution in the Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase generates protosta-13(17),24-dien-3β-ol, a rearrangement product
Tung-Kung Wu et al.
ORGANIC LETTERS (2008)
Importance of Saccharomyces cerevisiae Oxidosqualene-Lanosterol Cyclase Tyrosine 707 Residue for Chair-Boat Bicyclic Ring Formation and Deprotonation Reactions
Tung-Kung Wu et al.
ORGANIC LETTERS (2008)
Licorice β-amyrin 11-oxidase, a cytochrome P450 with a key role in the biosynthesis of the triterpene sweetener glycyrrhizin
Hikaru Seki et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Arabidopsis camelliol C synthase evolved from enzymes that make pentacycles
Mariya D. Kolesnikova et al.
ORGANIC LETTERS (2007)
Enzymatic synthesis of cyclic triterpenes
Ikuro Abe
NATURAL PRODUCT REPORTS (2007)
Phenylalanine 445 within oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae influences C-ring cyclization and deprotonation reactions
Tung-Kung Wu et al.
ORGANIC LETTERS (2006)
Cation-π interaction in the polyolefin cyclization cascade uncovered by incorporating unnatural amino acids into the catalytic sites of squalene cyclase
Noriko Morikubo et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)
Site-saturated mutagenesis of histidine 234 of Saccharomyces cerevisiae oxidosqualene-lanosterol cyclase demonstrates dual functions in cyclization and rearrangement reactions
Tung-Kung Wu et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2006)
Tryptophan 232 within oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae influences rearrangement and deprotonation but not cyclization reactions
TK Wu et al.
ORGANIC LETTERS (2006)
A putative precursor of isomalabaricane triterpenoids from lanosterol synthase mutants
S Lodeiro et al.
ORGANIC LETTERS (2006)
Enzymatic formation of indole-containing unnatural cyclic polyprenoids by bacterial squalene:hopene cyclase
H Tanaka et al.
ORGANIC LETTERS (2005)
A case study in biomimetic total synthesis: Polyolefin carbocyclizations to terpenes and steroids
RA Yoder et al.
CHEMICAL REVIEWS (2005)
Enzymatic cyclizations of squalene analogs with threo- and erythro-diols at the 6,7- or 10,11-positions by recombinant squalene cyclase. Trapping of carbocation intermediates and mechanistic insights into the product and substrate specificities
T Abe et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2005)
Enzymatic cyclization of 26-and 27-methylidenesqualene to novel unnatural C31 polyprenoids by squalene:hopene cyclase
H Tanaka et al.
TETRAHEDRON LETTERS (2004)
Enzymatic cyclization of 22,23-dihydro-2,3-oxidosqualene into euph-7-en-3β-ol and bacchar-12-en-3β-ol by recombinant β-amyrin synthase
I Abe et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)
The monotopic membrane protein human oxidosqualene cyclase is active as monomer
A Ruf et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
1-methylidenesqualene and 25-methylidenesqualene as active-site probes for bacterial Squalene:Hopene cyclase
H Tanaka et al.
ORGANIC LETTERS (2004)
Site-directed mutagenesis experiments on the putative deprotonation site of squalene-hopene cyclase from Alicyclobacillus acidocaldarius
T Sato et al.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2004)
On the origins of triterpenoid skeletal diversity
R Xu et al.
PHYTOCHEMISTRY (2004)
Enzymatic formation of multiple triterpenes by mutation of tyrosine 510 of the oxidosqualene-lanosterol cyclase from Saccharomyces cerevisiae
TK Wu et al.
CHEMBIOCHEM (2004)
Conversion of squalene to the pentacarbocyclic hopene
DJ Reinert et al.
CHEMISTRY & BIOLOGY (2004)
Purification, tandem mass characterization, and inhibition studies of oxidosqualene-lanosterol cyclase enzyme from bovine liver
TK Wu et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2004)
Oxidosqualene cyclase second-sphere residues profoundly influence the product profile
S Lodeiro et al.
CHEMBIOCHEM (2004)
Squalene-hopene cyclase: insight into the role of the methyl group on the squalene backbone upon the polycyclization cascade. Enzymatic cyclization products of squalene analogs lacking a 26-methyl group and possessing a methyl group at C(7) or C(11)
S Nakano et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2004)
Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase
R Thoma et al.
NATURE (2004)
Squalene-hopene cyclase: final deprotonation reaction, conformational analysis for the cyclization of (3R,S)-2,3-oxidosqualene and further evidence for the requirement of an isopropylidene moiety both for initiation of the polycyclization cascade and for the formation of the 5-membered E-ring
T Hoshino et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2004)
Enzymatic cyclization reactions of geraniol, farnesol and geranylgeraniol, and those of truncated squalene analogs having C-20 and C-25 by recombinant squalene cyclase
T Hoshino et al.
ORGANIC & BIOMOLECULAR CHEMISTRY (2004)
Mechanism and stereochemistry of enzymatic cyclization of 24,30-bisnor-2,3-oxidosqualene by recombinant β-amyrin synthase
I Abe et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2004)
Enzymatic formation of an unnatural novel tetracyclic sesterterpene by β-amyrin synthase
H Noma et al.
TETRAHEDRON LETTERS (2004)
Mutagenesis approaches to deduce structure-function relationships in terpene synthases
MJR Segura et al.
NATURAL PRODUCT REPORTS (2003)
Enzymatic formation of an unnatural hexacyclic C35 polyprenoid by bacterial squalene cyclase
I Abe et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2002)
Importance of the methyl group at C(10) of squalene for hopene biosynthesis and novel carbocyclic skeletons with 6/5+5/5+(6) ring system(s)
T Hoshino et al.
ORGANIC LETTERS (2002)
Squalene-hopene cyclase: catalytic mechanism and substrate recognition
T Hoshino et al.
CHEMICAL COMMUNICATIONS (2002)
Enzymic products of the 2,3-oxidosqualene analog having an ethyl residue at 10-position. First trapping of the trimethylcyclohexanone ring by lanosterol synthase
T Hoshino et al.
TETRAHEDRON LETTERS (2001)
Steric bulk at cycloartenol synthase position 481 influences cyclization and deprotonation
SPT Matsuda et al.
ORGANIC LETTERS (2000)
Mutational studies on triterpene syntheses:: Engineering lupeol synthase into β-amyrin synthase
T Kushiro et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2000)
Steric bulk at position 454 in Saccharomyces cerevisiae lanosterol synthase influences B-ring formation but not deprotonation
BM Joubert et al.
ORGANIC LETTERS (2000)
分享论文
