期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 15, 期 41, 页码 8705-8708出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ob02319g
关键词
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资金
- National Natural Science Foundation of China [21576296, 21776318, 81703365]
- China Postdoctoral Science Foundation [2017 M610504]
- Central South University
A diversity-driven three-component 1,3-dipolar cycloaddition of isatins, amino acids and isatin-derived ketimines was developed to facilely assemble dispirooxindole-imidazolidine skeletons bearing vicinal quaternary carbon centers. This protocol features additive-free, minimal solvent usage (0.1 mL DMSO/0.2 mmol scale), wide substrate scope (34 examples), mild reaction conditions (room temperature) and high chemical yield (up to 99%).
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