期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 15, 期 6, 页码 1329-1333出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ob02449a
关键词
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资金
- National Natural Science Foundation of China [21602179, 21502157]
- Fundamental Research Funds for the Central Universities [XDJK2015C154]
- Start-up Foundation of Southwest University Grant [SWU114056]
A convergent and efficient NHC-catalyzed enantioselective tandem Michael addition/lactonization sequence of ynals with 1,2-dione as the dual-nucleophile is disclosed. This straightforward strategy expeditiously assembles the synthetically and pharmaceutically valuable optically active fused dihydropyranones in good to high yields (70-88%) and with excellent enantioselectivities (92-99% ee).
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