4.6 Article

Carbon annulation of ortho-vinylanilines with dimethyl sulfoxide to access 4-aryl quinolines

期刊

ORGANIC & BIOMOLECULAR CHEMISTRY
卷 15, 期 6, 页码 1334-1337

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ROYAL SOC CHEMISTRY
DOI: 10.1039/c6ob02714h

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资金

  1. National Natural Science Foundation of China [21572025, 21672028]
  2. Key University Science Research Project of the Jiangsu Province [15KJA150001]
  3. Jiangsu Key Laboratory of Advanced Catalytic Materials Technology [BM2012110]

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A palladium-catalyzed annulation of ortho-vinylanilines with dimethyl sulfoxide was developed to access 4-aryl quinolines in moderate to good yields. Activated by 1,4-diazabicyclo[2.2.2] octane bis(sulfur dioxide) adduct (DABSO), DMSO served as a =CH- fragment in this transformation. It represents a facile pathway leading to 4-aryl quinolines.

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