期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 15, 期 33, 页码 6867-6887出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ob01662j
关键词
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The intermolecular cross-benzoin and acyloin condensation reactions are powerful approaches to alpha-hydroxy carbonyls in a single step. However, their potentiality suffers from the occurrence of side reactions including self-condensation and the formation of the undesired cross-acyloin. The broad range of azolium salt precatalysts available confers high tunability to NHC mediated benzoin condensation, assuring a good level of selectivity to the direct coupling between two non-equivalent aldehydes. Many efforts have also been devoted to the design of strategies that expand the range of suitable reaction partners beyond the traditional aldehydes and to the discovery of novel umpolung catalytic systems. The synthesis of both racemic and enantiomerically enriched acyloins is reviewed.
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