期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 15, 期 19, 页码 4036-4041出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ob00189d
关键词
-
资金
- Academy of Finland [285971]
- Academy of Finland (AKA) [285971, 285971] Funding Source: Academy of Finland (AKA)
Streptomyces soil bacteria are competent chemists that are able to produce thousands of chemically complex natural products. Key to the development of this rich source of metabolites appears to be an evolutionary pressure that promotes chemical diversity; new biosynthetic pathways are continuously being formed in these bacteria, which may result in the appearance of a novel bioactive compound that provides significant competitive advantage to the producing organism. In recent years, our work has focused on understanding how minor changes in the biosynthetic enzymes has led to drastically altered catalytic properties. We have generated chimeric proteins from functionally distinct homologous enzymes involved in the tailoring steps of related anthracycline and angucycline pathways, with the aim of creating novel catalysts. The work provides an opportunity for further protein engineering efforts for production of improved bioactive natural products.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据