期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 15, 期 26, 页码 5549-5555出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ob01160a
关键词
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资金
- Okayama Foundation for Science and Technology
- Yakumo Foundation for Environmental Science
- Grants-in-Aid for Scientific Research [17K05862, 17K05863] Funding Source: KAKEN
Hybrid molecules consisting of geraniol and butenolide were designed and synthesized by the late-stage divergent strategy. In the synthetic route, ring-closing metathesis was utilized for the construction of a butenolide moiety. A biological evaluation of the eight synthetic hybrid compounds revealed that these molecules exhibit antifouling activity against the cypris larvae of the barnacle Balanus (Amphibalanus) amphitrite with EC50 values of 0.30-1.31 mu g mL(-1). These results show that hybridization of the geraniol and butenolide structural motifs resulted in the enhancement of the antifouling activity.
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