期刊
ORGANIC & BIOMOLECULAR CHEMISTRY
卷 15, 期 7, 页码 1570-1574出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7ob00129k
关键词
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Acquiring a divergent response from homologous protein domains is essential for selective ligand-protein interactions. Stereospecific fluorination of (-)-balanol, an ATP mimic, uncovers a new source of selectivity from integrated chemical and conformational perturbation that differentiates homologous sites by the level of congruency in their response to local and remote fluorine effects.
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