期刊
RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
卷 44, 期 5, 页码 492-503出版社
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S1068162018050035
关键词
synthetic antimicrobial peptides; amphiphilicity; antimicrobial activity; drugs; cytotoxicity; selectivity; pathogenic bacteria and fungi
资金
- Program of Fundamental Scientific Research of State Academies of Sciences [0309-2016-0004, 0309-2016-0002]
Comparative antimicrobial properties of three artificial cationic synthetic antimicrobial peptides (SAMP): (RAhaR)(4)AhaA (where R is Arg, Aha is 6-aminohexanoic acid, A is beta-alanine), (KFF)(3)K and R9F2 with various amphiphilic properties have been studied relative to pathogenic strains of microorganisms: Gram-negative bacteria Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis, and Salmonella enterica, Gram-positive bacteria Staphylococcus aureus, and pathogenic yeast fungus Candida albicans. The selectivity index (SI) values of the peptide preparations were calculated as the ratio of the 50% cytotoxic concentration (TC50) towards eukaryotic host cells to the MIC50 values of the testing antimicrobial peptides. The studied SAMPs appeared to be the most active against the pathogenic yeast fungus C. albicans and the bacterial strains St. aureus and P. aeruginosa. The SI values in these cases exceed 40. Some assumed molecular interactions of the studied SAMPs on the microbial cells have been considered, and possible pathways to increase their antimicrobial activity have been suggested. The proposed SAMPs can serve as a basis for the design and synthesis of new promising synthetic antimicrobial agents.
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