期刊
OPTICS LETTERS
卷 42, 期 7, 页码 1365-1368出版社
OPTICAL SOC AMER
DOI: 10.1364/OL.42.001365
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- Canadian Institutes of Health Research (CIHR)
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- Brain Canada Michael Smith Foundation for Health Research (MSFHR)
- Alzheimer Society of Canada
Adaptive Optics (AO) for scanning laser ophthalmoscopy enables high-resolution retinal imaging that can be used for preclinical research of diseases causing vision loss. Pupil Segmentation (PS) is an approach to wavefront-sensorless AO that acquires images within subregions across the imaging pupil to measure the wavefront slopes at the corresponding locations of the beam. We present PS-AO as an approach to correct ocular aberrations in similar to 7 s, implemented to minimize respiratory motion from an anesthetized mouse. We demonstrated an improvement in resolution and an image intensity increase of similar to 25% across all results using PS-AO for in vivo fluorescence retinal imaging in mice using a MEMS-based segmented deformable mirror. (C) 2017 Optical Society of America
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