期刊
OPTICS EXPRESS
卷 25, 期 15, 页码 17105-17113出版社
OPTICAL SOC AMER
DOI: 10.1364/OE.25.017105
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资金
- National Natural Science Foundation of China [61575128, 61425007, 61635007]
- Guangdong Natural Science Foundation [2015A030313541, 2014B050504010, 2014A030308007]
- Science and Technology Innovation Commission of Shenzhen [JCYJ20160520163134575, JCYJ20160523113602609, JCYJ20150324141711611, JCYJ20150324141711614, JCYJ20150324141711576]
- Science and Technology Program of Shenzhen [GRCK2016082611242959]
- Pearl River Scholar Fellowships
We propose and experimentally verify an innovative label-free optical fiber biosensor based on a Mach-Zehnder interferometer for bovine serum albumin (BSA) concentration detection. The proposed fiber biosensor utilized a micro-cavity within a single-mode fiber to induce Mach-Zehnder interference. A remarkable feature of this biosensor is that external media can directly interact with the fiber core signal through microfluidic channels connected to the micro-cavity and sensor surface. The device was fabricated by means of femtosecond laser micromachining and chemical etching. A fiber interferometer of this type exhibits an ultrahigh refractive index sensitivity of -10,055 nm/RIU and a detection limit of 3.5 x 10(-5) RIU. Different concentrations of BSA with an infinitesimally small refractive index difference can be clearly differentiated in situ by the interferential spectra of the structure. Experiments demonstrated the biosensor exhibited a BSA solution concentration sensitivity of -38.9 nm/(mg/mL) and a detection limit of 2.57 x 10(-4) mg/mL, respectively. Moreover, this biosensor is a sub-microliter dose and ultrasensitive at the low concentrations detected in BSA, which make it a promising for biochemical applications such as DNA hybridization, cancer screenings, medicine examination and environmental engineering, etc. (C) 2017 Optical Society of America
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