期刊
PHYSICAL REVIEW E
卷 98, 期 4, 页码 -出版社
AMER PHYSICAL SOC
DOI: 10.1103/PhysRevE.98.042136
关键词
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资金
- EPSRC [EP/J019526/1]
- Wellcome Trust [108867/Z/15/Z]
- BBSRC [BB/H017828/1] Funding Source: UKRI
- EPSRC [EP/N018060/1, EP/P025021/1] Funding Source: UKRI
We demonstrate the phenomenon of cumulative inertia in intracellular transport involving multiple motor proteins in human epithelial cells by measuring the empirical survival probability of cargoes on the microtubule and their detachment rates. We found the longer a cargo moves along a microtubule, the less likely it detaches from it. As a result, the movement of cargoes is non-Markovian and involves a memory. We observe memory effects on the scale of up to 2 s. We provide a theoretical link between the measured detachment rate and the superdiffusive Levy-walk-like cargo movement.
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