期刊
OPTICS EXPRESS
卷 25, 期 23, 页码 28914-28934出版社
Optica Publishing Group
DOI: 10.1364/OE.25.028914
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资金
- LABEX WIFI (Laboratory of Excellence within the French Program Investments for the Future) [ANR-10-LABX-24, ANR-10-IDEX-0001-02 PSL*]
- European Research Council (ERC Synergy HELMHOLTZ)
- French Direction Generale de l'Armement(DGA)
Optical microscopy offers a unique insight of biological structures with a sub-micrometer resolution and a minimum invasiveness. However, the inhomogeneities of the specimen itself can induce multiple scattering of light and optical aberrations which limit the observation to depths close to the surface. To predict quantitatively the penetration depth in microscopy, we theoretically derive the single-to-multiple scattering ratio in reflection. From this key quantity, the multiple scattering limit is deduced for various microscopic imaging techniques such as confocal microscopy, optical coherence tomography and related methods. (C) 2017 Optical Society of America
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