期刊
CANCERS
卷 10, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/cancers10100366
关键词
ovarian cancer; tumor-associated macrophages; peritoneal metastasis; tumor microenvironment
类别
资金
- [5R01CA214043-02]
- [2P30CA168524-06]
- [5P30CA068485-21]
Ovarian cancer, a rare but fatal disease, has been a challenging area in the field of gynecological cancer. Ovarian cancer is characterized by peritoneal metastasis, which is facilitated by a cross-talk between tumor cells and other cells in the tumor microenvironment (TME). In epithelial ovarian cancer, tumor-associated macrophages (TAMs) constitute over 50% of cells in the peritoneal TME and malignant ascites, and are potential targets for therapy. Here, we review the bipolar nature of TAMs and the evolving strategies to target TAMs in ovarian cancer.
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