期刊
CHEMICAL COMMUNICATIONS
卷 54, 期 86, 页码 12234-12237出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c8cc05113e
关键词
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资金
- BBSRC [BB/L014130/1, BBS/E/J/000C0618, BBS/E/J/000PR9790] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/L014130/1, BBS/E/J/000PR9790, BBS/E/J/000C0618] Funding Source: Medline
In the context of discovering and quantifying terminal alkyne-based natural products, here we report the combination of CuAAC click chemistry with LC-MS for the detection of polyether toxins (prymnesins) associated with harmful algal blooms. The added-value of the CuAAC-based approach is evident from our ability to detect novel prymnesin-like compounds in algal species with previously uncharacterised toxins.
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