4.2 Article

SAVE-AMD: Safety of VEGF Inhibitors in Age-Related Macular Degeneration

期刊

OPHTHALMOLOGICA
卷 238, 期 4, 页码 205-216

出版社

KARGER
DOI: 10.1159/000478665

关键词

Age-related macular degeneration; Endothelial function; Vascular endothelial growth factor; Clinical trial; Ranibizumab; Bevacizumab

资金

  1. Swiss National Science Foundation [32003B_130840]
  2. Swiss Heart Foundation
  3. Werner H. Spross Foundation for Ophthalmology
  4. Bandung Foundation
  5. Austrian Science Fund - FWF (Erwin Schrodinger Stipendium) [J3559-B23]
  6. Swiss National Science Foundation (SNF) [32003B_130840] Funding Source: Swiss National Science Foundation (SNF)

向作者/读者索取更多资源

Objective: To determine whether intraocular treatment with vascular endothelial growth factor (VEGF) inhibitors change systemic endothelial function (EF) in patients with neovascular age-related macular degeneration (AMD). Methods: In this prospective, randomized, 2-center, double-masked controlled interventional trial, patients with neovascular and dry AMD were enrolled. Eligible neovascular AMD patients received 2 intravitreal loading doses of either ranibizumab 0.5 mg or bevacizumab 1.25 mg at 4-week intervals and were subsequently followed every 4 weeks and treated according to a pro re nata regime for up to 1 year. Patients with dry AMD served as controls. The primary endpoint was the change in EF assessed by flow-mediated dilatation (FMD) after 2 months of treatment with VEGF inhibitors in patients with AMD compared to patients with dry AMD. FMD was assessed with B-mode high-resolution ultrasonography of the left brachial artery. Results: 24 patients with neovascular AMD and 26 patients with dry ADM were included in the trial. Treatment with VEGF inhibitors did not significantly change FMD (from 4.7 +/- 2.4 to 3.9 +/- 1.9% after 8 weeks, p = 0.07, and to 5.1 +/- 2.0% after 1 year; p = 0.93 vs. baseline, respectively). Conclusions: EF did not significantly differ between patients with neovascular AMD treated with intravitreal VEGF inhibition and patients with dry AMD. (C) 2017 The Author(s) Published by S. Karger AG, Basel

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