期刊
ONCOLOGY RESEARCH
卷 25, 期 2, 页码 187-194出版社
COGNIZANT COMMUNICATION CORP
DOI: 10.3727/096504016X14732772150389
关键词
miR-422a; Insulin-like growth factor 1 (IGF1); Insulin-like growth factor 1 receptor (IGF1R); Glioma
类别
资金
- International S&T Cooperation Program of China [2014DFA31630]
- National Nature Science Foundation of China [81571646]
- Specialized Research Fund for the Doctoral Program of Higher Education [20132307110029]
- Scientific Foundation of The First Affiliated Hospital of Harbin Medical University [2011BS13]
- Natural Science Foundation of Heilongjiang Province [H201434]
- Application Technology Research and Development Project of Heilongjiang Province [GA15C108, GA15C103-01]
Glioma is a common type of malignant brain tumor characterized by aggressive metastasis capability. Recent evidence has suggested that noncoding RNAs, including microRNAs, have important functions in the pathophysiology of glioma development. In this study, we investigated the biological function of miR-422a in human glioma. We found that miR-422a was downregulated in glioma tissues. We also demonstrated that expression of miR-422a in glioma cells markedly suppressed cell proliferation, migration, and invasion. In addition, we identified insulin-like growth factor 1 (IGF1) and IGF1 receptor (IGF1R) as inhibitory targets of miR-422a in glioma cells. We established that the expression levels of miR-422a were negatively correlated with the expression levels of IGF1/IGF1R and the clinical parameters in glioma patients. An IGFR inhibitor, AG1024, completely blocked the activity of miR-442a on glioma cell proliferation and invasion, which further confirmed that miR-422a functions through IGF1 and IGF1R.
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