期刊
ONCOLOGY REPORTS
卷 37, 期 3, 页码 1359-1366出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/or.2017.5416
关键词
lncRNAs; autophagy; autophagy-associated diseases; molecular mechanism; cancers
类别
资金
- National Natural Science Foundation of China [81572946]
- Changsha Science and Technology Project [k1508024-31]
- Clinical and Rehabilitation Research Foundation of Xiangya Hospital Beidaweiming
Identification of long non-coding RNAs (lncRNAs) has provided a substantial increase in our understanding of the non-coding transcriptome. Studies have revealed a crucial function of IncRNAs in the modulation of cell autophagy in vitro and in vivo, further contributing to the hallmarks of disease phenotypes. These findings have profoundly altered our understanding of disease pathobiology, and may lead to the emergence of new biological concepts underlying autophagy-associated diseases, such as the carcinomas. Studies on the molecular mechanism of the lncRNA-autophagy axis may offer additional avenues for therapeutic intervention and biomarker assessment. In this review, we discuss recent findings on the multiple molecular roles of regulatory IncRNAs in the signaling pathways of cell autophagy. The emerging knowledge in this rapidly advancing field will offer novel insights into human diseases, especially cancers.
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