期刊
CEREBRAL CORTEX
卷 28, 期 11, 页码 3894-3907出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/cercor/bhx253
关键词
Cognitive Performance; dopamine D-2/3 Receptor Availability; Heterogeneity; Latent Profile Analysis; Older Adults; Working Memory
资金
- Swedish Research Council [446-2013-7189]
- FORTE [2013-2277]
- Umea University-Karolinska Institute Strategic Neuroscience program
- Knut and Alice Wallenberg Foundation
- Torsten Soderberg Foundation
- Ragnar Soderberg Foundation
- Alexander von Humboldt Research award
- Max Planck Society
- Gottfried Wilhelm Leibniz Research Award of the German Research Foundation (DFG)
- Emmy Nother Programme from the DFG
- Umea University
- Swedish National Infrastructure for Computing (SNIC) through the Abisko computer cluster at Umea University
- Swedish Brain Power
- Swedish Brain Foundation
- Vasterbotten County Council
Evidence suggests that associations between the neurotransmitter dopamine and cognition are nonmonotonic and open to modulation by various other factors. The functional implications of a given level of dopamine may therefore differ from person to person. By applying latent-profile analysis to a large (n = 181) sample of adults aged 64-68 years, we probabilistically identified 3 subgroups that explain the multivariate associations between dopamine D2/3R availability (probed with C-11-raclopride-PET, in cortical, striatal, and hippocampal regions) and cognitive performance (episodic memory, working memory, and perceptual speed). Generally, greater receptor availability was associated with better cognitive performance. However, we discovered a subgroup of individuals for which high availability, particularly in striatum, was associated with poor performance, especially for working memory. Relative to the rest of the sample, this subgroup also had lower education, higher body-mass index, and lower resting-state connectivity between caudate nucleus and dorsolateral prefrontal cortex. We conclude that a smaller subset of individuals induces a multivariate non-linear association between dopamine D2/3R availability and cognitive performance in this group of older adults, and discuss potential reasons for these differences that await further empirical scrutiny.
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