期刊
ONCOLOGY REPORTS
卷 39, 期 3, 页码 1052-1062出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/or.2017.6175
关键词
paeoniflorin; Skp2; glioma
类别
资金
- Program of Medical Innovation Team and Leading Talent of Jiangsu Province, China [LJ201150]
- Science and Technology Plan Projects of Jiangsu Province, China [BL2012048]
- National Natural Sciences Foundation of China [81572480]
Paeoniflorin (PF), a natural compound isolated from Paeoniae radix, has been shown to exert antitumor effects in various types of human cancers including glioma. However, the mechanism of action is not well understood. S-phase kinase-associated protein (Skp)2 functions as an oncogene in many cancers. In the present study, we investigated whether Skp2 mediates the anti-glioma activity of PF. We found that PF inhibited glioma cell proliferation, migration and invasion, and induced G2/M arrest and apoptosis. Skp2 expression was downregulated in glioma cells treated with PF. PF-induced antitumor effects in glioma cells were abolished by Skp2 overexpression but were enhanced by RNA interference of Skp2. Moreover, PF treatment inhibited U87 cell-derived tumor growth in a xenograft mouse model. These results demonstrate that PF exerts its antitumor effects in part by inhibiting Skp2 expression in glioma cells and could be a promising therapeutic agent for glioma therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据