期刊
ONCOGENE
卷 36, 期 30, 页码 4323-4335出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/onc.2017.74
关键词
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资金
- National High-tech Research and Development Projects (863) [2012AA021103]
- National Natural Science Foundation of China (NSFC) [81402423, 81572818]
- Science and Technology Commission of Shanghai Municipality [13JC1404100, 14YF1402800]
N-myc downstream-regulated gene 1 (NDRG1) has been reported to act as a key regulatory molecule in tumor progression-related signaling pathways, especially in tumor metastasis. However, the related mechanism has not been fully discovered yet. Herein we demonstrated that the novel molecule of cell migration and invasion, caveolin-1, has direct interaction with NDRG1 in human colorectal cancer (CRC) cells. Moreover, we discovered that NDRG1 reduces caveolin-1 protein expression through promoting its ubiquitylation and subsequent degradation via the proteasome in CRC cells. In addition, caveolin-1 mediates the suppressive function of NDRG1 in epithelial-mesenchymal transition, migration and invasion in vitro and metastasis in vivo. These results help to fulfill the potential mechanisms of NDRG1 in anti-metastatic treatment for human colorectal cancer.
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