期刊
ONCOGENE
卷 37, 期 3, 页码 302-312出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/onc.2017.341
关键词
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资金
- NIH [P01 CA114046, P01 CA025874, P30 CA010815, R01 CA047159, CA076674, CA182890]
- Melanoma Research Alliance
- Dr. Miriam and Sheldon G. Adelson Medical Research Foundation
- Vienna Science and Technology Fund (WWTF) [LS11-045]
- Vienna Hans Mayr-Fund
- APART fellowship of the Austrian Academy of Sciences
Melanoma is a heterogeneous tumor with different subpopulations showing different proliferation rates. Slow-cycling cells were previously identified in melanoma, but not fully biologically characterized. Using the label-retention method, we identified a subpopulation of slow-cycling cells, defined as label-retaining cells (LRC), with strong invasive properties. We demonstrate through live imaging that LRC are leaving the primary tumor mass at a very early stage and disseminate to peripheral organs. Through global proteome analyses, we identified the secreted protein SerpinE2/protease nexin-1 as causative for the highly invasive potential of LRC in melanomas.
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