Choroidal and Retinal Anatomical Responses Following Systemic Corticosteroid Therapy in Vogt-Koyanagi-Harada Disease Using Swept-Source Optical Coherence Tomography

Purpose: To assess structural changes in retina and choroid after systemic corticosteroid therapy in Vogt-Koyanagi-Harada (VKH) disease using swept-source optical coherence tomography (SS-OCT). Methods: SS-OCT was conducted before treatment and during first-month follow-up in 16 eyes treated with systemic corticosteroids for active VKH. Retina was divided into five zones depending on pretreatment choroidal thickness (CT) of <100, >100 to <200, >200 to <300, >300 to 400 mu m, and changes in retinal thickness and CT after treatment in these zones were compared with baseline. Results: Mean CT significantly improved from 83.1 +/- 8.75 to 156.4 +/- 62.73 mu m(p = 0.008) in the zone with pre-CT <100 mu m and significantly decreased from 336.1 +/- 17.28 to 266.28 +/- 81.39 mu m(p = 0.008) in the zone with pre-CT > 300 mu m. Conclusions: We have shown choroidal remodeling in VKH. SS-OCT can serve as an important noninvasive tool in assessment of treatment response in patients with VKH disease.