期刊
IEEE ACCESS
卷 6, 期 -, 页码 62988-62994出版社
IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
DOI: 10.1109/ACCESS.2018.2876919
关键词
Optical fiber devices; optical coherence tomography; fiber optics imaging; intravascular imaging
资金
- National Research Foundation Singapore [NRF-CRP13-2014-05]
- National Natural Science Foundation of China [61705184, 81401451]
- Ministry of Education Singapore [MOE2013-T2-2-107]
- National Medical Research Council Singapore [NMRC/CBRG/0036/2013]
- NTU-AIT-MUV Program in Advanced Biomedical Imaging [NAM/15005]
Development and progression of coronary atherosclerotic lesions is mediated by a number of cellular components that are not readily visualized using the current clinical investigation tools. Visualizing these cellular components in situ and in vivo may allow early detection of the vulnerable plaques, with implications for coronary artery disease therapy and for the prevention of acute myocardial infarction. In this paper, we have developed a fiber-optic micro-optical coherence tomography (mu OCT) probe for intravascular use. We conducted ex vivo imaging experiments in normal swine aorta and human atherosclerotic coronary arteries and demonstrated that the fiber-probe-based mu OCT could delineate not only the layered structures of arterial wall but also the cellular-level anatomical structures of atherosclerotic plaques, including foam cells and smooth muscle cells. These results demonstrate the feasibility of intravascular mu OCT imaging.
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