期刊
GOLD BULLETIN
卷 51, 期 4, 页码 163-173出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s13404-018-0241-4
关键词
Gold nanoparticle; Trophic transfer; Toxicity; Natural biofilm; Fish; Hypostomus plecostomus
资金
- Agence Nationale de la Recherche (ANR) in the CITTOXIC-Nano program [ANR-14-CE21-0001-01]
- Investments for the Future Program, within the Cluster of Excellence COTE [ANR-10-LABX-45]
- French Ministry of Research
- Agence Nationale de la Recherche (ANR) [ANR-14-CE21-0001] Funding Source: Agence Nationale de la Recherche (ANR)
Nanoparticle (NP) trophic transfer is reported as an important exposure route for organisms in aquatic ecosystems. This study focused on gold nanoparticle (AuNP, PEG-coated, 10nm diameter) transfer using an experimental benthic food chain which included two trophic levels: natural river biofilm and grazer fish Hypostomus plecostomus. AuNP biofilm accumulation was assessed via water AuNP concentrations and total biofilm mass. An extended range of six AuNP concentrations in water (0, 0.0048, 0.048, 0.48, 4.8, and 48mg Au L-1) was set. A dose-dependent relation between gold concentrations in water and natural river biofilm was observed after a 48-h exposure. This pointed out the high propensity of natural biofilms to accumulate gold. Additionally, total biofilm mass appeared to influence AuNP accumulation at the highest exposure levels. This first step enables the set-up of the transfer experiment in which grazer fish were exposed for 21days to natural biofilms, previously contaminated by low AuNP concentrations in water (NP0.1: 0.48 and NP1: 4.8mg Au L-1). Gold was quantified in eight fish organs, and histology was observed. Gold was transferred from biofilms to fish; bioaccumulation was organ- and exposure level-dependent. Interestingly, the brain showed significant gold accumulation at the highest exposure level (NP1). Histological observations indicated distinct inflammatory responses in fish liver, spleen, and muscle. The overall results suggest the potential hazards of subchronic nanoparticle exposure in aquatic organisms.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据