期刊
OBESITY SURGERY
卷 28, 期 3, 页码 702-711出版社
SPRINGER
DOI: 10.1007/s11695-017-2903-3
关键词
Bariatric surgery; Type 2 diabetes mellitus; Roux-en-Y gastric bypass; Class I obesity; Low body mass index
类别
资金
- National Natural Science Foundation of China [81502613]
- Sichuan Province Science and Technology Support Program [2014SZ0002-5]
- Xindu Social Science and Technology Development Project [20160740401]
Laparoscopic Roux-en-Y gastric bypass (LRYGB) has been proven to be effective on treating type 2 diabetes mellitus (T2DM) in severely obese patients, but whether LRYGB surgery should be performed in obese class I patients is controversial. A retrospective study of 3-year bariatric and metabolic outcomes in different obese class T2DM patients who underwent LRYGB was conducted to compare the effectiveness of LRYGB in obese class I patients with that in obese class II/III patients in a Chinese T2DM population. Totally, 58 patients with class I obesity and 45 patients with class II/III obesity were enrolled in this study. Major complications included two cases of incomplete intestinal obstructions and one anastomotic leak. The remission rates of T2DM were 70.6% in obese class I group and 77.8% in obese class II/III group at 1 year after surgery and 55.6 versus 64.3% at 3 years (all P > 0.05). Logistic regression analysis showed that higher waist circumference, lower fasting plasma glucose, and higher FCP at 2 h of OGTT were independently associated with diabetes remission at 1 year after surgery. At 1 year and thereafter, the percentage of excess weight loss was significantly greater in obese class II/III patients. At 3 years, body mass index was not significantly different between the two groups, and the obese class I patients had high recurrence rates of hypertension and hyperuricemia. LRYGB surgery is feasible, safe, and effective in Chinese obese class I patients with T2DM.
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