期刊
DATA IN BRIEF
卷 17, 期 -, 页码 356-362出版社
ELSEVIER
DOI: 10.1016/j.dib.2018.01.024
关键词
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资金
- National Institute of Health [GM31954]
- Alfred and Mabel Gilman Chair in Molecular Pharmacology
- U.S. Department of Energy, Office of Biological and Environmental Research [DE-AC02-06CH11357]
The Pleckstrin homology (PH) domains from the Lbc family of Rho Guanine Nucleotide Exchange Factors (Lbc RhoGEFs) interact with activated Rho family GTPases. All 7 Lbc RhoGEFs associate directly with activated Rho GTPases via their PH domains. However, the binding affinities between the PH domains and the GTPases vary greatly. Here we present two crystal structures at resolutions of 1.4 angstrom and 2.0 angstrom of RhoA complexed with the PH domain from p114RhoGEF (PDB access code 6BCB) and AIKAP-LbcRhoGEF (PDB access code 6BCA), respectively. These high resolution structures, together with the earlier structures of PDZRhoGEF-PH-RhoA and p190RhoGEF-PH-RhoA complexes, identify a highly conserved interface between the PH domains from Lbc-RhoGEFs and activated Rho GTPases. This manuscript is related to the manuscript titled Direct Regulation of p190RhoGEF by Activated Rho and Rac GTPases published in the Journal of Structural Biology. Published by Elsevier Inc.
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