期刊
OBESITY
卷 25, 期 9, 页码 1594-1602出版社
WILEY
DOI: 10.1002/oby.21926
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资金
- National Institute for Environmental Health Sciences (NIEHS) [P01ES022844]
- US Environmental Protection Agency (US EPA) [RD83543601]
- Michigan Nutrition Obesity Research Center [P30 DK089503]
- Michigan Regional Comprehensive Metabolomics Resource Core [R24 DK097153]
- Robert C. and Veronica Atkins Foundation
- National Institute of Public Health/Ministry of Health of Mexico
ObjectiveThe goal of this study was to identify metabolites associated with metabolic risk, separately by sex, in Mexican adolescents. MethodsUntargeted metabolomic profiling was carried out on fasting serum of 238 youth aged 8 to 14 years, and metabolites associated with a metabolic syndrome risk z-score (MetRisk z-score) were identified separately for boys and girls, using the simulation and extrapolation algorithm. Associations of each metabolite with MetRisk z-score were examined using linear regression models that accounted for maternal education, child's age, and pubertal status. ResultsOf the 938 features identified in metabolomics analysis, 7 named compounds (of 27 identified metabolites) were associated with MetRisk z-score in girls, and 3 named compounds (of 14 identified) were associated with MetRisk z-score in boys. In girls, diacylglycerol (DG) 16:0/16:0, 1,3-dielaidin, myo-inositol, and urate corresponded with higher MetRisk z-score, whereas N-acetylglycine, thymine, and dodecenedioic acid were associated with lower MetRisk z-score. For example, each z-score increment in DG 16:0/16:0 corresponded with 0.60 (95% CI: 0.47-0.74) units higher MetRisk z-score. In boys, positive associations of DG 16:0/16:0, tyrosine, and 5-methylthioadenosine with MetRisk z-score were found. ConclusionsMetabolites on lipid, amino acid, and carbohydrate metabolism pathways are associated with metabolic risk in girls. Compounds on lipid and DNA pathways correspond with metabolic risk in boys.
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