期刊
NUTRITION RESEARCH REVIEWS
卷 30, 期 1, 页码 118-137出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0954422417000026
关键词
Diet; Immunomodulation; Lupus; Nutrients; Systemic lupus erythematosus
资金
- Ministerio de Economia y Competitividad, ISCIII, Eur J Nutr 1 3 FEDER [AGL 2011-26949]
- Junta de Andalucia [P-10AGR-6609]
- Postgraduate National Programme of FPU fellowship [FPU2012/03430]
- Spanish Ministerio de Educacion, Cultura y Deporte
Systemic lupus erythematosus (SLE) is a chronic inflammatory and autoimmune disease characterised by multiple organ involvement and a large number of complications. SLE management remains complicated owing to the biological heterogeneity between patients and the lack of safe and specific targeted therapies. There is evidence that dietary factors can contribute to the geoepidemiology of autoimmune diseases such as SLE. Thus, diet therapy could be a promising approach in SLE owing to both its potential prophylactic effects, without the side effects of classical pharmacology, and its contribution to reducing co-morbidities and improving quality of life in patients with SLE. However, the question arises as to whether nutrients could ameliorate or exacerbate SLE and how they could modulate inflammation and immune function at a molecular level. The present review summarises preclinical and clinical experiences to provide the reader with an update of the positive and negative aspects of macro- and micronutrients and other nutritional factors, including dietary phenols, on SLE, focusing on the mechanisms of action involved.
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