期刊
ADVANCED THERAPEUTICS
卷 1, 期 8, 页码 -出版社
WILEY
DOI: 10.1002/adtp.201800068
关键词
adaptive morphologies; drug delivery; nanomedicine; nanotechnology
资金
- National Natural Science Foundation of China [NSFC 51561135010, 51773146, 51633005]
- Dutch Ministry of Education, Culture and Science [024.001.035]
- NWO-NSFC Advanced Materials [792.001.015]
- ERC [694120]
- European Union [663830, 676137]
- Ser Cymru II programme
Intrigued and inspired by the intricacy of natural architectures which display various morphologies, researchers seek to develop artificial counterparts in order to replicate, and thereby harness, their function for diverse applications. In particular, well-defined nanoparticles with various morphologies are of great interest for biomedical research. The impact of morphologically discrete nanoparticles upon the development of nanomedicine is significant, gaining increasing attention for its potential to provide a new avenue for the development of future therapeutic technologies. This progress report discusses adaptive morphologies based on block copolymers as platforms for therapeutic and smart drug delivery applications, including design rationale and controlling the morphology of polymeric nanoparticles. The proof-of-concept studies on influence of shapes of nanoparticles on their anticancer effects in vitro and in vivo are addressed.
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