期刊
JACC-BASIC TO TRANSLATIONAL SCIENCE
卷 3, 期 6, 页码 844-857出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jacbts.2018.09.004
关键词
atherosclerosis; diabetes; GLP-1; inflammation; obesity
The glucagon-like peptide-1 receptor agonists (GLP-1RAs) liraglutide and semaglutide reduce cardiovascular risk in type 2 diabetes patients. The mode of action is suggested to occur through modified atherosclerotic progression. In this study, both of the compounds significantly attenuated plaque lesion development in apolipoprotein E-deficient (ApoE(-/-)) mice and low-density lipoprotein receptor-deficient (LDLr-/-) mice. This attenuation was partly independent of weight and cholesterol lowering. In aortic tissue, exposure to a Western diet alters expression of genes in pathways relevant to the pathogenesis of atherosclerosis, including leukocyte recruitment, leukocyte rolling, adhesion/extravasation, cholesterol metabolism, lipid-mediated signaling, extracellular matrix protein turnover, and plaque hemorrhage. Treatment with semaglutide significantly reversed these changes. These data suggest GLP-1RAs affect atherosclerosis through an anti-inflammatory mechanism. (C) 2018 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.
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