期刊
EMERGING INFECTIOUS DISEASES
卷 24, 期 12, 页码 2241-2250出版社
CENTERS DISEASE CONTROL & PREVENTION
DOI: 10.3201/eid2412.180937
关键词
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资金
- Shaw Foundation
- Michael Seak-Kan Tong
- Consultancy Service for Enhancing Laboratory Surveillance of Emerging Infectious Disease for Department of Health of the Hong Kong Special Administrative Region of China
- Enhanced New Staff Start-up Research Grant of the University of Hong Kong
- Pfizer Corporation Hong Kong
- Astellas Pharma Hong Kong Corporation Limited
- Seed Fund for Basic Research
All hepatitis E virus (HEV) variants reported to infect humans belong to the species Orthohepevirus A (HEV-A). The zoonotic potential of the species Orthohepevirus C (HEV-C), which circulates in rats and is highly divergent from HEV-A, is unknown. We report a liver transplant recipient with hepatitis caused by HEV-C infection. We detected HEV-C RNA in multiple clinical samples and HEV-C antigen in the liver. The complete genome of the HEV-C isolate had 93.7% nt similarity to an HEV-C strain from Vietnam. The patient had preexisting HEV antibodies, which were not protective against HEV-C infection. Ribavirin was an effective treatment, resulting in resolution of hepatitis and clearance of HEV-C viremia. Testing for this zoonotic virus should be performed for immunocompromised and immunocompetent patients with unexplained hepatitis because routine hepatitis E diagnostic tests may miss HEV-C infection. HEV-C is also a potential threat to the blood product supply.
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