Tackling guanidinoacetic acid for advanced cellular bioenergetics

Tissues with high-energy output, such as the brain and skeletal muscle, suffer the most from impaired or depleted energy levels, with innovative nutritional approaches needed to effectively tackle metabolic deficits in bioenergetics. Here, we highlight the role of guanidinoacetic acid in the control and provision of cellular energy by its interaction with cellular transporters for taurine (SLC6 A6) and gamma-aminobutyric acid (SLC6 A13), previously dismissed as untargetable carriers by other bioenergetics therapeutics. (C) 2016 Elsevier Inc. All rights reserved.