期刊
NUCLEIC ACIDS RESEARCH
卷 46, 期 D1, 页码 D335-D342出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkx1038
关键词
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资金
- Biotechnology and Biological Sciences Research Council (BBSRC) [BB/M011690/1]
- Howard Hughes Medical Institute
- US National Institutes of Health [1-R01-HG009116]
- Research Councils UK (RCUK)
- BBSRC [BB/M011690/1] Funding Source: UKRI
The Rfam database is a collection of RNA families in which each family is represented by a multiple sequence alignment, a consensus secondary structure, and a covariance model. In this paper we introduce Rfam release 13.0, which switches to a new genome-centric approach that annotates a non-redundant set of reference genomes with RNA families. We describe new web interface features including faceted text search and R-scape secondary structure visualizations. We discuss a new literature curation workflow and a pipeline for building families based on RNAcentral. There are 236 new families in release 13.0, bringing the total number of families to 2687. The Rfam website is http://rfam.org.
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