Human Ageing Genomic Resources: new and updated databases

In spite of a growing body of research and data, human ageing remains a poorly understood process. Over 10 years ago we developed the Human Ageing Genomic Resources (HAGR), a collection of databases and tools for studying the biology and genetics of ageing. Here, we present HAGR'smain functionalities, highlighting new additions and improvements. HAGR consists of six core databases: (i) the GenAge database of ageing-related genes, in turn composed of a dataset of> 300 human ageing-related genes and a dataset with > 2000 genes associated with ageing or longevity in model organisms; (ii) the AnAge database of animal ageing and longevity, featuring > 4000 species; (iii) the GenDR database with > 200 genes associated with the life-extending effects of dietary restriction; (iv) the LongevityMap database of human genetic association studies of longevity with > 500 entries; (v) the DrugAge database with > 400 ageing or longevity-associated drugs or compounds; (vi) the CellAge database with > 200 genes associated with cell senescence. All our databases are manually curated by experts and regularly updated to ensure a high quality data. Cross-links across our databases and to external resources help researchers locate and integrate relevant information. HAGRis freely available online (http://genomics.senescence.info/).