期刊
NUCLEIC ACIDS RESEARCH
卷 46, 期 D1, 页码 D477-D485出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkx1019
关键词
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资金
- Swiss Institute of Bioinformatics, Service and Infrastructure
- UK Biotechnology and Biological Sciences Research Council [BB/L018241/1, BB/M009513/1]
- University College London, UCL Impact Award
- Bayer Crop Science NV
- University College Library
- Biotechnology and Biological Sciences Research Council [1618923] Funding Source: researchfish
- BBSRC [1618923, BB/L018241/1] Funding Source: UKRI
The Orthologous Matrix (OMA) is a leading resource to relate genes across many species from all of life. In this update paper, we review the recent algorithmic improvements in the OMA pipeline, describe increases in species coverage (particularly in plants and early-branching eukaryotes) and introduce several new features in the OMA web browser. Notable improvements include: (i) a scalable, interactive viewer for hierarchical orthologous groups; (ii) protein domain annotations and domain-based links between orthologous groups; (iii) functionality to retrieve phylogenetic marker genes for a subset of species of interest; (iv) a new synteny dot plot viewer; and (v) an overhaul of the programmatic access (REST API and semantic web), which will facilitate incorporation of OMA analyses in computational pipelines and integration with other bioinformatic resources. OMA can be freely accessed at https://omabrowser.org.
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