期刊
NUCLEIC ACIDS RESEARCH
卷 46, 期 D1, 页码 D618-D623出版社
OXFORD UNIV PRESS
DOI: 10.1093/nar/gkx1012
关键词
-
资金
- EMBL postdoctoral fellowship
- EMBL
- MRC
- Medical Research Council [MR/K020420/1] Funding Source: researchfish
- MRC [MR/K020420/1] Funding Source: UKRI
M-CSA (Mechanism and Catalytic Site Atlas) is a database of enzyme active sites and reaction mechanisms that can be accessed at www.ebi.ac.uk/thornton-srv/m-csa. Our objectives with M-CSA are to provide an open data resource for the community to browse known enzyme reaction mechanisms and catalytic sites, and to use the dataset to understand enzyme function and evolution. M-CSA results from themerging of two existing databases, MACiE (Mechanism, Annotation and Classification in Enzymes), a database of enzymemechanisms, and CSA (Catalytic Site Atlas), a database of catalytic sites of enzymes. We are releasing M-CSA as a new website and underlying database architecture. At the moment, MCSA contains 961 entries, 423 of these with detailed mechanism information, and 538 with information on the catalytic site residues only. In total, these cover 81% (195/241) of third level EC numbers with a PDB structure, and 30% (840/2793) of fourth level EC numbers with a PDB structure, out of 6028 in total. By searching for close homologues, we are able to extend M-CSA coverage of PDB and UniProtKB to 51 993 structures and to over five million sequences, respectively, of which about 40% and 30% have a conserved active site.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据